From McGill


  • Celia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Stella Xu, Sandra Minotti, Tad Wu, Heather Durham, Gene W. Yeo, Maria Vera. Localized synthesis of molecular chaperones sustains neuronal proteostasis. BioRxiv. doi:
  • Wenshuai Wang, Fei Liu, Maria Vera Ugalde, Anna Marie Pyle. A compact regulatory RNA element in mouse Hsp70 mRNA. BioRxiv.doi:
  • Alagar Boopathy LR, Beadle E, Garcia-Bueno Rico A, Vera M. Proteostasis regulation through ribosome quality control and no-go-decay. Wiley Interdiscip Rev RNA. 2023 Jul 24:e1809. doi: 10.1002/wrna.1809. PMID: 37488089
  • Alagar Boopathy LR, Beadle E, Xiao AR, Garcia-Bueno Rico A, Alecki C, Garcia de-Andres I, Edelmeier K, Lazzari L, Amiri M, Vera M. The ribosome quality control factor Asc1 determines the fate of HSP70 mRNA on and off the ribosome. Nucleic Acids Res. 2023 May 9;gkad338. doi: 10.1093/nar/gkad338. PMID: 37158240 DOI: 10.1093/nar/gkad338


  • Wefers, Z.* & Alecki, C.*, Huang R., Jacob-Tomas, S., and Vera, M. Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment. Cells. 11(12):1877. PMID:35741005. (*) = Equal contribution to this work.
  • Jacob-Tomas, S.* & Alagar Boopathy, L.R.*, and Vera, M. Using single-molecule fluorescence microscopy to uncover neuronal vulnerability to protein damage. Invited contribution to Methods in Molecular Biology: Neuronal Cell Death: Methods and Protocols. 2022;2515:237-254  (*) = Equal contribution to this work. PMID: 35776356.
  • Alagar Boopathy, L.R.* & Jacob-Tomas, S.*, Alecki, C., and Vera, M. Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges. Invited contribution to J Biol Chem. 2022 Mar 3;101796. PMID: 35248532. (*) = Equal contribution to this work.
  • Alecki, C. and Vera, M. Role of nuclear non-canonical nucleic acid structures in organismal development and adaptation to stress conditions. Front Genet. 2022 Feb 23;13:823241. PMID: 35281835.


  • Das, S., Vera, M., Gandin, V., Singer, R.H.*, and Tutucci, E*.  Intracellular mRNA transport and localized translation. Nature Review in Molecular Cell Biology. Jul;22(7):483-504. PMID: 33837370.


  • Sato. H* & Das. S*, Singer. RH and Vera, M.  Imaging of DNA and RNA in Living Eukaryotic Cells to Reveal Spatiotemporal Dynamics of Gene Expression. Annual Review of Biochemistry, Vol (89). PMID:32176523.

First-author publications (Ph.D. and Postdoc)

  • Vera, M., Tutucci, E., and Singer, R.H. (2019). The new MS2 system as a tool to visualize single mRNAs in mammalian cells. Methods in Molecular Biology. 2038:3-20. PMID: 31407274.
  • Tutucci, E.*, & Vera, M.*, Biswas, J., Garcia, J., Parker, R., and Singer, R.H. (2018). An improved MS2 system for accurate reporting of the mRNA life cycle. Nature Methods, 15(1): 81-89. (*) = Equal contribution to this work. F1000 recommended.
  • Vera, M., Biswas, J., Senecal, A., Singer, R.H., and Park H.Y. (2016). Single-cell and single-molecule analysis of gene expression regulation. Annual Rev. Genet., 50: 267-291. PMCID: PMC5149423.
  • Hocine, S.* & Vera, M.*, Zenklusen, D., and Singer R.H. (2015). Promoter-Autonomous Functioning in a Controlled Environment using Single Molecule FISH. Sci Rep., 5: 9934. PMCID: PMC4446897. (*) = Equal contribution to this work.
  • Vera, M., Pani, B., Griffiths, L.A., Muchardt, C., Abbott, C.M., Singer, R.H., and Nudler, E. (2014). eEF1A1 couples transcription to translation during heat shock. Elife., 3: e03164. PMCID: PMC4164936.
  • Vera, M. and Singer, R.H. (2014). Gene Regulation: the HSP70 gene jumps when shocked. Current Biol., 24(10): R396-8. PMCID: PMC4156153.
  • Vera, M., Sobrevals, L., Zaratiegui, M., Martinez, L., Palencia, B., Rodríguez, C.M., Prieto, J., and Fortes, P. (2007). Liver transduction with a simian virus 40 vector encoding insulin-like growth factor I reduces hepatic damage and the development of liver cirrhosis. Gene Ther., 14(3): 203-10. PMID: 17024107.
  • Vera, M., Razquin, N., Prieto, J., Melero, I., Fortes, P., and González-Aseguinolaza, G. (2005). Intratumoral injection of dendritic cells transduced by an SV40-based vector expressing interleukin-15 induces curative immunity mediated by CD8+ T lymphocytes and NK cells. l Ther., 12(5): 950-9. PubMed PMID: 15921960.
  • Vera, M., Prieto, J., Strayer, D.S., and Fortes, P. (2004). Factors influencing the production of recombinant SV40 vectors. Ther., 10(4): 780-91. PMID: 15451462.
  • Vera, M. and Fortes, P. (2004). Simian virus-40 as a gene therapy vector. DNA Cell Biol., 23(5): 271-82. Review. PMID: 15169607.


  • Tutucci, E., Vera, M., and Singer, R.H. Single mRNA detection in living S. cerevisiae using a re-engineered MS2 system. Nature Protocols. Oct;13(10):2268-2296. PMID: 30218101.
  • Doig, J., Griffiths, L.A., Peberdy, D., Dharmasaroja, P., Vera, M., Davies, F.J., Newbery, H.J., Brownstein, and D., Abbott, C.M. (2013). In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy. FEBS J., 280(24): 6528-40. PMCID: PMC4163635.
  • Urtasun, R., Cubero, F.J., Vera, M., and Nieto, N. (2009). Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology, 136(4): 1410-22, PMID: 19250650.
  • Abad, X., Vera, M., Jung, S.P., Oswald, E., Romero, I., Amin, V., Fortes, P., and Gunderson, S.I. (2008). Requirements for gene silencing mediated by U1 snRNA binding to a target sequence. Nucleic Acids Res., 36(7): 2338-52. PMCID: PMC2367729.
  • Narvaiza, I.*, Aparicio, O.*, Vera, M., Razquin, N., Bortolanza, S., Prieto, J., and Fortes, P. (2006). Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing. Virol., 80(24): 12236-47. PMCID: PMC1676304.
  • Huarte, E., Tirapu, I., Arina, A., Vera, M., Alfaro, C., Murillo, O., Palencia, B., Busto, V., Marín, V., Mazzolini, G., and Melero, I. (2005). Intratumoral administration of dendritic cells: hostile environment and help by gene therapy. Expert Opin. Biol. Ther., 5(1): 7-22. Review. PMID: 15709906.
  • McKee, H.J., T’sao, P.Y., Vera, M., Fortes, P., and Strayer, D.S. (2004). Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 +/- IL-15. Vaccines Ther., 2(1): 10. PMCID: PMC517511.
  • Pérez-Caballero, D., González-Rubio, C., Gallardo, M.E., Vera, M., López-Trascasa, M., Rodríguez de Córdoba, S., and Sánchez-Corral, P. (2001). Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome. J. Hum. Genet., 68(2): 478-84. PMCID: PMC1235280.

María Vera Ugalde

McIntyre Medical Sciences Building
3655 promenade Sir-William-Osler
Montreal, Quebec H3G 1Y6